EGFR-IN-150

SKU: orb3028683

Description

EGFR-IN-150 is an EGFR inhibitor that effectively inhibits the phosphorylation of mutant epidermal growth factor receptor (EGFR) and its downstream AKT signaling pathway, exerting antitumor effects and inducing HMOX1 expression to trigger ferroptosis. This compound exhibits an IC50 of 0.386 μM against the non-small cell lung cancer (NSCLC) cell line H1975 and significantly suppresses the colony formation and migration abilities of H1975 and A549 cells, while also inducing apoptosis. Additionally, EGFR-IN-150 prominently reduces tumor growth in H1975 tumor-bearing mouse CDX models. It holds promise for research related to non-small cell lung cancer.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3037323-16-0
• MW: 522.985
• Formula: C₂₉H₂₃ClN₆O₂
• SMILES: C(=C\1/C=2C(NC1=O)=CC=C(NC=3N=C(NC4=C(NC(C=C)=O)C=CC=C4)C(Cl)=CN3)C2)\C5=C(C)C=CC=C5
• Target: EGFR,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,Apoptosis