EGFR-IN-144

SKU: orb2945483

Description

EGFR-IN-144 (Compound 4B) inhibits EGFR (IC50=0.639 µg/mL) and tubulin polymerization (IC50=7.339 µg/mL). It exhibits cytotoxicity in various cancer cells with a GI50 at the nanomolar level. EGFR-IN-144 reduces the expression of mTOR, TNF-α, and IL-6, causes G1/S phase cell cycle arrest, and induces apoptosis.

Key Properties

• MW: 418.273
• Formula: C₂₀H₁₇Cl₂N₃O₃
• SMILES: CC1=C(N=NN1C2=C(C=C(C=C2)Cl)Cl)C(=O)/C=C/C3=CC(=C(C=C3)OC)OC
• Target: EGFR,Microtubule Associated,TNF,Apoptosis,Interleukin

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,Microtubule Associated,TNF,Apoptosis,Interleukin