EGFR-IN-141

SKU: orb2945127

Description

EGFR-IN-141 (Compound 8I) is a potent EGFR inhibitor (IC50 = 2.67 nM) demonstrating cytotoxic activity in A549 cells (IC50 = 13.75 µM). It induces apoptosis and mitochondrial membrane depolarization, supporting its investigation as a potential antitumor agent in cancer research, including studies of non-small cell lung carcinoma (NSCLC) mechanisms.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3054263-27-0
• MW: 482.514
• Formula: C₂₀H₁₅FN₈O₂S₂
• SMILES: O=C1C=2C=CC=CC2N=CN1CC3=NN=C(SCC(=O)NC4=NC=5C=CC(F)=CC5S4)N3N
• Target: EGFR,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172677436