EGFR-IN-136

SKU: orb2945318

Description

EGFR-IN-136 (compound 21v) is a potent EGFR inhibitor with IC50 values ranging from 1.2 to 20.2 nM against various EGFR mutants, including those relevant to NSCLC. It demonstrates antiproliferative activity in vitro and antitumor efficacy in vivo, making it a valuable tool for oncology research, particularly in studying resistance mechanisms and targeted therapies for non-small cell lung cancer.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• MW: 589.625
• Formula: C₃₀H₃₆N₇O₄P
• SMILES: CC1=CN=C2NC3=C(C=C(C(=C3)C4=CN(CCCOC5=CC(=C(C=C5)NC1=N2)P(=O)(C)C)N=C4)N6CCOCC6)OC
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676937