EGFR-IN-134

SKU: orb2802394

Description

EGFR-IN-134 is a potent triazoloquinoline-based EGFR inhibitor (IC50: 0.023 µM) that exhibits anticancer activity by inducing apoptosis, necrosis, and G2/M cell cycle arrest. It modulates key apoptotic proteins, including downregulating Bcl-2 and upregulating p53, Bax, and caspases. This compound is a valuable tool for in vitro cancer research, particularly in studying EGFR-driven proliferation and cell death mechanisms.

Research Area

Cardiovascular Research, Cell Biology, Protein Biochemistry, Signal Transduction

Key Properties

• MW: 626.66
• Formula: C₃₆H₃₀N₆O₅
• SMILES: O=C(C1=NN(C2=CC=C([N+]([O-])=O)C=C2)C3N1CCC4=C3C=C(OC)C(OC)=C4)/C=C/C5=CN(C6=CC=CC=C6)N=C5C7=CC=CC=C7
• Target: Necroptosis,EGFR,Bcl-2 Family,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419289