EGFR-IN-133

SKU: orb2802180

Description

EGFR-IN-133 (Compound 24) is a potent, orally bioavailable EGFR inhibitor effective against wild-type and multiple resistant mutations, including L858R/T790M and C797S variants, with IC50 values in the sub-nanomolar range. It is a valuable research tool for in vitro and in vivo studies exploring resistance mechanisms and therapeutic strategies in non-small cell lung cancer.

Research Area

Cardiovascular Research, Cell Biology, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 2809982-26-9
• MW: 537.56
• Formula: C₂₇H₂₉F₂N₇O₃
• SMILES: FC1=C2N3C(NC2=CC(N[C@@H]4CCOC4)=C1)=NC(=O)C=5C=C(C6=C(OCCC[C@@H](C)C3)N(C)N=C6)N=C(F)C5
• Target: EGFR,Antifungal

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419257