EGFR-IN-132

SKU: orb2802330

Description

EGFR-IN-132 is a potent and orally bioavailable EGFR inhibitor targeting multiple mutations, including L858R/T790M and C797S resistance variants, with IC50 values in the sub-nanomolar range. It is a valuable research tool for studying resistance mechanisms and evaluating antitumor efficacy in both cellular and animal models of non-small cell lung cancer.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2809982-20-3
• MW: 501.58
• Formula: C₂₇H₃₁N₇O₃
• SMILES: C[C@H]1CN2C=3C(NC2=NC(=O)C=4C=C(C5=C(OCCC1)N(C)N=C5)N=C(C)C4)=CC(NC6COC6)=CC3
• Target: EGFR,Neurotensin Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176419281