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EGFR-IN-126

SKU: orb2665147

Description

EGFR-IN-126 (compound 9d) is a potent small molecule inhibitor targeting the EGFR L858R/T790M/C797S triple mutant, with an IC50 of 5 nM. It demonstrates robust antitumor efficacy in both cellular assays and animal models, making it a valuable chemical probe for studying resistant non-small cell lung cancer (NSCLC).

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number2890621-88-0
MW567.45
FormulaC28H28BrFN4O3
SMILESFC=1C=CC=CC1OC2=CC=C(C=C2Br)NC=3N=CN=C4C=C(OCC5CCN(C)CC5)C(OC)=CC43
TargetEGFR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

EGFR-IN-126 (orb2665147)

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