EGFR-IN-126

SKU: orb2665147

Description

EGFR-IN-126 (compound 9d) is a potent small molecule inhibitor targeting the EGFR L858R/T790M/C797S triple mutant, with an IC50 of 5 nM. It demonstrates robust antitumor efficacy in both cellular assays and animal models, making it a valuable chemical probe for studying resistant non-small cell lung cancer (NSCLC).

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2890621-88-0
• MW: 567.45
• Formula: C₂₈H₂₈BrFN₄O₃
• SMILES: FC=1C=CC=CC1OC2=CC=C(C=C2Br)NC=3N=CN=C4C=C(OCC5CCN(C)CC5)C(OC)=CC43
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166515235