EGFR-IN-11

SKU: orb1709792

Description

EGFR-IN-11 is a potent and selective EGFR tyrosine kinase inhibitor that induces apoptosis and causes G0/G1 phase cell cycle arrest. It demonstrates high potency against the resistant triple mutant EGFRL858R/T790M/C797S with an IC50 of 18 nM. This compound is a valuable tool for in vitro research in non-small cell lung cancer and studies of acquired EGFR inhibitor resistance.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2463200-44-2
• MW: 573.71
• Purity: 99.93%
• Formula: C₂₉H₃₅N₉O₂S
• SMILES: CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n([C@@H]4CCN(C4)S(=O)(=O)C4CC4)c3n2)cc1
• Target: Apoptosis,EGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.97 mM);DMSO:112.5 mg/mL (196.09 mM)

Bioactivity

• Target IC50:
  EGFR (L858R/T790M/C797S):18 nM
• In Vitro:
  EGFR-IN-11 (0.1 nM-10 µM) shows anti-proliferation with IC50s of 0.88 nM, 0.20 µM and 2.91 μM for HCC827, H1975 and A549 cells. EGFR-IN-11 (10nM-10 µM) suppresses the phosphorylation of EGFR in a concentration-dependent manner in the HCC827, H1975 and A549 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EGFR, EGFRIN11, EGFR-IN-11, EGFR IN 11, EGFRL858R/T790M/C797S

Compound Identifiers

PubChem CID

145712397