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EGFR-IN-1

SKU: orb1709794

Description

EGFR-IN-1 is a potent, orally bioavailable, and irreversible EGFR inhibitor with high selectivity for L858R/T790M mutant forms, including those resistant to gefitinib. It demonstrates robust antiproliferative effects in vitro, such as in H1975 and HCC827 cell lines, and has shown antitumor efficacy in relevant in vivo xenograft models.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1625677-63-5
MW514.58
FormulaC28H30N6O4
SMILESO=C1N(C=2C(=CN=C(NC3=C(OC)C=C(OCCN(C)C)C=C3)N2)C(C)=C1)C4=CC(NC(C=C)=O)=CC=C4
TargetEGFR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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EGFR-IN-1 (orb1709794)

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