Eg5 Inhibitor V, trans-24

SKU: orb1709797

Description

Trans-24 is a potent and specific small molecule inhibitor of the mitotic kinesin Eg5, with an IC50 of 0.65 µM. It is a valuable chemical probe for studying cell division mechanisms and has been utilized in both in vitro biochemical assays and in vivo cancer research models to investigate antimitotic therapies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 869304-55-2
• MW: 423.46
• Purity: 99.75% (May vary between batches)
• Formula: C₂₆H₂₁N₃O₃
• SMILES: [H][C@@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)N(Cc1ccccc1)C2=O)c1cccc(O)c1
• Target: Kinesin
• Solubility: DMSO:45 mg/mL (106.27 mM)

Bioactivity

• Target IC50:
  EG5:0.65 μM
• In Vitro:
  Trans-24 is a potent EG5-specific inhibitor with an IC50 conversion rate of 0.65 M and can be used in cancer research.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Eg5, Eg5 Inhibitor V, trans 24, Eg5 Inhibitor V, trans24, Eg-5 Inhibitor V, trans-24, Eg5 Inhibitor V, trans-24

Compound Identifiers

PubChem CID

11553595