EG31

SKU: orb3027912

Description

EG31 is an EGFR inhibitor that effectively suppresses the proliferation of triple-negative breast cancer (TNBC) cells by inhibiting the EGFR signaling pathway. It demonstrates a GI50 value of 498.90 nM for MDA-MB-231 cells and 740.73 nM for Hs578T cells, while also inducing apoptosis. Additionally, EG31 retains its antiproliferative activity against 5-fluorouracil (5-FU) resistant TNBC cells, with a GI50 of 519.5 nM. EG31 is applicable in research on TNBC resistance.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 360760-58-3
• MW: 671.25
• Formula: C₃₀H₁₃Br₂N₃O₆
• SMILES: O=C1OC(=NC2=CC=C(Br)C=C12)C=3C=C(C=C(C3)N4C(=O)C=5C=CC=CC5C4=O)C6=NC7=CC=C(Br)C=C7C(=O)O6
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR