Formoterol hemifumarate

SKU: orb1300709

Description

Formoterol fumarate is a potent, selective, and long-acting β2-adrenergic receptor agonist used in respiratory disease research. It is widely applied in studies of asthma and COPD, serving as a key pharmacological tool for investigating bronchodilation in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 43229-80-7
• MW: 402.5
• Purity: >99%
• Formula: C₁₉H₂₄N₂O₄ • ½C₄H₄O₄
• SMILES: OC(=O)\C=C\C(O)=O.COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1.COc1ccc(C[C@H](C)NC[C@@H](O)c2ccc(O)c(NC=O)c2)cc1
• Target: GPCR
• Solubility: Soluble in DMSO (up to 20 mg/ml)

Bioactivity

• In Vivo:
  Formoterol is a high-affinity, selective β2-adrenergic receptor agonist that effectively relaxes airway smooth muscles. Similar to salbutamol and salmeterol, it relaxes guinea pig trachea and human bronchi in vitro in a concentration-dependent manner and inhibits the release of antigen-induced inflammatory mediators in human lung slices.
• In Vitro:
  In guinea pig lungs, Formoterol at a concentration of 100 mg/mL inhibits Platelet-Activating Factor (PAF)-induced eosinophil aggregation and suppresses Porcine Pancreatic Elastase (PPE) activity for 2-4 hours. In conscious guinea pigs, Formoterol dose-dependently inhibits histamine-induced plasma protein leakage and bronchoconstriction. Significant inhibition of histamine-induced effects was observed at doses of 10 mg/mL and 100 mg/mL. Additionally, a higher concentration of Formoterol is required to inhibit neutrophil aggregation (induced by Lipopolysaccharides) compared to its ability to suppress granulocyte-independent PPE (induced by histamine).

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BD 40A

Compound Identifiers

PubChem CID

9832292