Difluoromethylornithine HCl

SKU: orb1305288

Description

Eflornithine hydrochloride hydrate (DFMO) is an irreversible ornithine decarboxylase (ODC) inhibitor. It is used in research for its antitumor properties and has clinical application in treating hirsutism. Studies utilize it in both in vitro and in vivo models to investigate polyamine metabolism in cancer and dermatology.

Research Area

Cell Biology

Key Properties

• CAS Number: 96020-91-6
• MW: 236.7
• Purity: >98%
• Formula: C₆H₁₂F₂N₂O₂ • HCl • H₂O
• SMILES: O.Cl.NCCCC(N)(C(F)F)C(O)=O
• Target: Polyamine
• Solubility: Soluble in Water (up to 25 mg/ml).

Bioactivity

• In Vivo:
  Eflornithine stands as the only novel compound registered for human African trypanosomiasis treatment in the past five decades, primarily serving as an alternative for cases resistant to melarsoprol involving Trypanosoma brucei gambiense. Additionally, a 15% eflornithine cream demonstrates efficacy superior to placebo in diminishing excessive, unwanted facial hair growth in patients, with 58% of individuals treated with eflornithine observing at least some improvement in facial hirsutism after 24 weeks, compared to 34% of those receiving placebo. Furthermore, the inhibitory effect on hair growth by eflornithine cream is significantly amplified when applied to mouse skin previously treated with microneedles. In hypertensive rats with coarctation, eflornithine treatment normalizes contractile responses to KCI and norepinephrine, and enhances relaxations to acetylcholine within 14 days, indicating its broader pharmacological utility.
• In Vitro:
  When cultured cells are treated with α-difluoromethyl-Orn, an inhibitor of polyamine biosynthesis, production of hydrogen peroxide is suppressed and programmed cell death did not occur.
• Cell Research:
  BY2 cells are treated with or without cryptogein in the presence or absence of DFMO(Difluoromethylornithine) and monitered the effect of chemicals on cell growth. (Only for Reference)

Storage & Handling

• Storage: RT
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DFMO; Eflornithine

Compound Identifiers

PubChem CID

441361