Edg-2 receptor inhibitor 1

SKU: orb1689979

Description

SAR-100842 is a potent and selective inhibitor of the Edg-2 (LPA1) receptor with an IC50 of <0.1 µM. This small molecule is a valuable research tool for investigating lysophosphatidic acid (LPA) signaling in fibrosis, neuropathic pain, and cancer research using both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1195941-38-8
• MW: 445.51
• Purity: 99.69% (May vary between batches)
• Formula: C₂₇H₂₇NO₅
• SMILES: N(C(=O)C1=CC(OCCC2=CC(C)=CC=C2)=C(OC)C=C1)C3(C(O)=O)CC=4C(C3)=CC=CC4
• Target: LPA Receptor
• Solubility: DMSO:83.3 mg/mL (186.98 mM)

Bioactivity

• Target IC50:
  Edg2 receptor:<0.1 μM
• In Vitro:
  Edg-2 receptor inhibitor 1 is an inhibitor of the endothelial differentiation gene receptor 2 (Edg-2, EDG2), which is activated by lysophosphatidic acid (LPA) and is also termed as LPA1 receptor, and is useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Edg 2 receptor inhibitor 1, EDG2, Edg2 receptor inhibitor 1, Edg-2 receptor inhibitor 1, LPA Receptor, LPAReceptor, SAR 100842, SAR100842, SAR-100842

Compound Identifiers

PubChem CID

44481866