Ecteinascidin 770

SKU: orb1709800

Description

Ecteinascidin 770 is a small molecule that inhibits RNA-dependent RNA polymerase 1 (RDRP1), demonstrating antiviral activity against SARS-CoV-2 and antibacterial effects against Mycobacterium tuberculosis in vitro. Its primary research application is in oncology for studying cancer cell viability mechanisms.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 114899-80-8
• MW: 770.85
• Formula: C₄₀H₄₂N₄O₁₀S
• SMILES: [H][C@@]12Cc3cc(C)c(OC)c(O)c3[C@@]([H])(N1C)[C@@]1([H])N([C@H]2C#N)[C@@]2([H])COC(=O)[C@]3(CS[C@]1([H])c1c(OC(C)=O)c(C)c4OCOc4c21)NCCc1cc(O)c(OC)cc31
• Target: Others
• Solubility: DMSO:40 mg/mL (51.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.59 mM)

Bioactivity

• Target IC50:
  DU-145 cells:0.81 nM|U-373MG cells:4.83 nM|HCT116 cells:0.6 nM
• In Vitro:
  Methods: U373MG glioblastoma cells were treated with Ecteinascidin 770, and cytotoxicity was detected by MTT assay. Results: The IC 50 value of Ecteinascidin 770 against U373MG cells was 4.83 nM.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ecteinascidin 770, Ecteinascidine 770, Et770, Et-770, U373MG cell

Compound Identifiers

PubChem CID

10952807