Eclalbasaponin I

SKU: orb1297387

Description

Eclalbasaponin I exhibits anti-oxidative and antitumor properties, reducing oxidative stress-induced neural cell death via autophagy activation. It inhibits the proliferation of hepatoma SMMC-7721 cells with an IC50 of 111.1703 µg/ml, supporting its research in neuroprotection and oncology for in vitro studies.

Key Properties

• CAS Number: 158511-59-2
• MW: 796.98
• Purity: 99.90% (May vary between batches)
• Formula: C₄₂H₆₈O₁₄
• SMILES: [H][C@@]1(O[C@H]2CC[C@@]3(C)[C@@]([H])(CC[C@]4(C)[C@]3([H])CC=C3[C@]5([H])CC(C)(C)CC[C@@]5([C@H](O)C[C@@]43C)C(=O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C2(C)C)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
• Target: Others
• Solubility: DMSO:27.5 mg/mL (34.51 mM)

Bioactivity

• Target IC50:
  SMMC-7721 cells:111.1703 μg/ml (IC50)
• In Vitro:
  Four fractions (water, 30% ethanol, 60% ethanol and 90% ethanol) were obtained. Four compounds, wedelolactone (I), Eclalbasaponin I (II), luteolin (III) and luteolin-7-O-glucoside (IV) were purified and their structures were identified by the interpretation of spectroscopic analyses including MS, (1)H and (13)C NMR. Antitumor activities of extracts (total fraction), four fractions and the isolated compounds were assessed using hepatoma cell smmc-7721 as an in vitro assay system. The 30% ethanol fraction and Eclalbasaponin I dose-dependently inhibited the proliferation of hepatoma cell smmc-7721 with IC(50) values of 74.2399 and 111.1703 μg/ml, respectively, more strongly compared with 5-fluorouracil positive control group with the IC(50) value of 195.3131 μg/ml. Antitumor activities of other fractions and compounds were lower than positive control.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Eclalbasaponin I

Compound Identifiers

PubChem CID

10079039