Echinatin

SKU: orb1303555

Description

Echinatin

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 34221-41-5
• MW: 270.28
• Purity: 98.12%
• Formula: C₁₆H₁₄O₄
• SMILES: COc1cc(O)ccc1\C=C\C(=O)c1ccc(O)cc1
• Target: Autophagy,Free radical scavengers,NOD-like Receptor (NLR),Apoptosis
• Solubility: DMSO:20 mg/mL (74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4.9 mg/mL (18.13 mM);Chloroform:Soluble

Bioactivity

• In Vivo:
  METHODS: To test the antitumor activity in vivo, Echinatin (20-50 mg/kg) was administered by gavage to nude mice bearing KYSE270 xenografts every two days for 14 days. RESULTS: Tumor load was significantly suppressed, with a 57% and 48% reduction in the groups treated with 20 and 50 mg/kg Echinatin, respectively.Echinatin inhibited the AKT/mTOR pathway, as evidenced by a reduction in the expression levels of p-AKT and p-mTOR.
• In Vitro:
  METHODS: Esophageal squamous cell carcinoma cells KYSE30 and KYSE270 were treated with Echinatin (10-40 µM) for 1-5 days and cell viability was measured by CCK-8 assay. RESULTS: Echinatin significantly inhibited cell proliferation in a dose- and time-dependent manner. METHODS: Human osteosarcoma cells 143B and MG63 were treated with Echinatin (30-50 µM) for 24 h. Cell cycle was measured by Flow cytometry. RESULTS: Echinatin significantly increased the percentage of osteosarcoma cells in the S phase of the cell cycle.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Echinatin, inhibit, Inhibitor, Free radical scavengers, Freeradicalscavengers, Retrochalcone

Compound Identifiers

PubChem CID

6442675