EC330

SKU: orb1299948

Description

EC330

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2016795-77-8
• MW: 462.57
• Purity: 97.83%
• Formula: C₃₀H₃₂F₂O₂
• SMILES: [H][C@@]12CC[C@@](O)(C(F)(F)C#C)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)C1CC1
• Target: Interleukin,Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.32 mM);DMSO:20 mg/mL (43.24 mM)

Bioactivity

• In Vivo:
  EC330 treatment (0.5 and 2.5mg/kg) dose dependently reduced tumor burden in ovarian (IGROV-1) and triple negative breast cancer (MDA-MB-231) cell xenografted mouse models.
• In Vitro:
  EC330 blocked formation of colonies in soft agar and inhibited angiogenesis (tube formation) in human umbilical vein endothelial cells. EC330 binds to LIF/LIFR complex by insilico docking studies and reduced the STAT3 phosphorylation in a dose dependent manner through blocking LIF-JAK-STAT signaling. EC330 showed marked specificity in MCF-7 cells overexpressing LIF verses MCF-7 cells. The compound further showed cytoskeletal disruption and targeting cancer associated fibroblasts (CAFs).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EC 330, EC330, EC-330, inhibit, LIF, Inhibitor

Compound Identifiers

PubChem CID

127020967