EBV lytic cycle inducer-1

SKU: orb1944722

Description

EBV lytic cycle inducer-1 is a synthetic iron chelate analog designed to trigger the Epstein-Barr virus lytic replication phase. It is a valuable research tool for studying EBV reactivation mechanisms and viral oncolysis in both cellular and animal models.

Research Area

Infectious Disease & Virology, Infectious Disease & Virology; Cancer Biology

Key Properties

• CAS Number: 394668-43-0
• MW: 318.17
• Purity: >99.99% (May vary between batches)
• Formula: C₁₄H₁₂BrN₃O
• SMILES: O=C(NN=C(C1=NC=CC=C1)C)C=2C=CC=C(Br)C2
• Target: Antifection
• Solubility: DMSO:8.5 mg/mL (26.72 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.57 mM)

Bioactivity

• In Vitro:
  Dp44mT (EBV lytic cycle inducer-1)(compound C7) induces the lytic cycle in a cell-line-dependent manner, with a higher inductive capacity on AGS-BX1 cells compared to AGX cells, in the concentration range of 0-80 μM for 48 hours. At 10 μM, Dp44mT(EBV lytic cycle inducer-1) induces the lytic cycle in a time-dependent manner over 0-72 hours. At concentrations of 1.25-2.5 μM for 24 hours, Dp44mT(EBV lytic cycle inducer-1) synergistically induces the Epstein-Barr virus (EBV) lytic cycle with the HDAC inhibitors Romidespin and SAHA. At 20 μM for 48 hours, Dp44mT(EBV lytic cycle inducer-1) reactivates the EBV lytic cycle by inducing the ERK-autophagy axis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dp44mT, EBV, EBV lytic cycle inducer-1

Compound Identifiers

PubChem CID

872813