Eberconazole Nitrate

SKU: orb1299472

Description

Eberconazole Nitrate is a synthetic broad-spectrum imidazole antifungal agent. It is utilized in research for its activity against dermatophytes and yeasts, with applications in both in vitro susceptibility testing and in vivo models of cutaneous fungal infections.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 130104-32-4
• MW: 392.23
• Purity: 99.53%
• Formula: C₁₈H₁₅Cl₂N₃O₃
• SMILES: O[N+]([O-])=O.Clc1cc(Cl)c2C(c3ccccc3CCc2c1)n1ccnc1
• Target: Antifungal
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.1 mM);DMSO:25 mg/mL (63.74 mM)

Bioactivity

• In Vivo:
  Spherical and porous Eberconazole Nitrate(EB) microsponge particles were obtained. The optimized microsponges possessed particle size, drug content and entrapment efficiency of 24.5 μm, 43.31% and 91.44%, respectively. Microsponge-loaded gels demonstrated controlled release, nonirritancy to rat skin and antifungal activity. An in vivo skin deposition study demonstrated fourfold higher retention in the stratum corneum layer as compared with commercial cream.
• Animal Research:
  Eberconazole Nitrate(EB) microsponges were prepared using the quasiemulsion solvent diffusion method. The effect of formulation variables (drug:polymer ratio, internal phase volume and amount of emulsifier) and process variables (stirring time and stirring speed) on the physical characteristics of microsponges were investigated. The optimized microsponges were dispersed into a hydrogel and evaluated.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dichlorinated imidazole derivative, dermatophytose, Eberconazole, Eberconazole Nitrate, Ebernet, clotrimazole, antifungal, Antifungal, Fungal, ketoconazole, Inhibitor, inhibit, miconazole, topical administration

Compound Identifiers

PubChem CID

179851