Ebastine

SKU: orb1305656

Description

Ebastine is a selective, non-sedating H1 antihistamine that minimally crosses the blood-brain barrier, effectively inhibiting peripheral histamine receptors without central nervous system effects like drowsiness. It is widely used in research to study allergic responses and inflammation in both in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 90729-43-4
• MW: 469.66
• Purity: 99.65% (May vary between batches)
• Formula: C₃₂H₃₉NO₂
• SMILES: C(OC1CCN(CCCC(=O)C2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
• Target: Histamine Receptor
• Solubility: DMSO:4.7 mg/mL (10.01 mM)

Bioactivity

• In Vivo:
  Compared to H2 receptors, Ebastine showed selectivity for histamine H1, moderate activity against other potential mediators of allergic phenomena such as leukotriene C4 and platelet-activating factor, and was apparently effective in targeting allergic reaction antigens induced by exposure of appropriately sensitized tissues or animals to allergies.Ebastine inhibited, in human nasal polyp cells, anti-IgE-induced prostaglandin D2 and leukotriene C4/D4 with IC30 of 2.57 μM and 9.6 μM, respectively, and inhibited cytokine release.Ebastine also inhibited hERG-expressing IKr in African Xenopus oocytes with a Kd value of 0.3 μM, with a maximal inhibition of 46% at 3 μM.Ebastine exerted a small effect on transient potassium currents in rats at a concentration of less than 100 nM. Ebastine had a small effect on the transient potassium current in rats at concentrations less than 100 nM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiallergic, antihistamine, allergic, Inhibitor, inhibit, Kestine, H1 receptor, Ebastel, Ebastin, Ebastine, idiopathic, LAS-W 090, LAS-W090, LAS-W-090, HistamineReceptor, Histamine Receptor, RP 64305, RP64305, RP-64305, rhinitis, urticaria

Compound Identifiers

PubChem CID

3191