Ebastine

SKU: orb1305656

Description

Ebastine

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 90729-43-4
• MW: 469.66
• Purity: 99.99%
• Formula: C₃₂H₃₉NO₂
• SMILES: C(OC1CCN(CCCC(=O)C2=CC=C(C(C)(C)C)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
• Target: Histamine Receptor
• Solubility: DMSO:4.7 mg/mL (10.01 mM)

Bioactivity

• In Vivo:
  Compared to H2 receptors, Ebastine showed selectivity for histamine H1, moderate activity against other potential mediators of allergic phenomena such as leukotriene C4 and platelet-activating factor, and was apparently effective in targeting allergic reaction antigens induced by exposure of appropriately sensitized tissues or animals to allergies.Ebastine inhibited, in human nasal polyp cells, anti-IgE-induced prostaglandin D2 and leukotriene C4/D4 with IC30 of 2.57 μM and 9.6 μM, respectively, and inhibited cytokine release.Ebastine also inhibited hERG-expressing IKr in African Xenopus oocytes with a Kd value of 0.3 μM, with a maximal inhibition of 46% at 3 μM.Ebastine exerted a small effect on transient potassium currents in rats at a concentration of less than 100 nM. Ebastine had a small effect on the transient potassium current in rats at concentrations less than 100 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiallergic, antihistamine, allergic, Inhibitor, inhibit, Kestine, H1 receptor, Ebastel, Ebastin, Ebastine, idiopathic, LAS-W 090, LAS-W090, LAS-W-090, HistamineReceptor, Histamine Receptor, RP 64305, RP64305, RP-64305, rhinitis, urticaria

Compound Identifiers

PubChem CID

3191