Carebastine

SKU: orb1309874

Description

Carebastine is the active metabolite of the antihistamine Ebastine and functions as a selective histamine H1 receptor antagonist. It is widely used in pharmacological research to study allergic responses and receptor interactions in both in vitro binding assays and in vivo models of histamine-mediated processes.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 90729-42-3
• MW: 499.64
• Purity: 99.16%
• Formula: C₃₂H₃₇NO₄
• SMILES: CC(C)(C(O)=O)c1ccc(cc1)C(=O)CCCN1CCC(CC1)OC(c1ccccc1)c1ccccc1
• Target: MIF,Histamine Receptor
• Solubility: DMF:24 mg/mL (48.03 mM);DMSO:1 mg/mL (2 mM)

Bioactivity

• In Vitro:
  Carebastine inhibits VEGF-induced HPAEC and HUVEC proliferation, migration, and angiogenesis in a dose-dependent manner . Carebastine suppresses the expression of macrophage migration inhibitory factor .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Carebastine, H1 receptor, Inhibitor, HistamineReceptor, Histamine Receptor, inhibit

Compound Identifiers

PubChem CID

65820