EB1

SKU: orb1744050

Description

EB1 is a selective MNK1/2 kinase inhibitor with IC50 values of 0.69 µM and 9.4 µM, respectively. It suppresses eIF4E phosphorylation, inhibits cancer cell proliferation, and induces apoptosis in vitro, making it a useful research tool for oncology and translational control studies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 42951-68-8
• MW: 286.33
• Purity: 99.82% (May vary between batches)
• Formula: C₁₈H₁₄N₄
• SMILES: NC=1C2=C(C=C(N=C2NN1)C3=CC=CC=C3)C4=CC=CC=C4
• Target: MNK,Apoptosis,PERK
• Solubility: DMSO:50 mg/mL (174.62 mM)

Bioactivity

• Target IC50:
  HepG2 cells:0.74 μM|MNK2:9.4 μM|MCF-7 cells:5.18 μM|MNK1:0.69 μM
• In Vitro:
  EB1, in a dose-dependent manner (1.3-40 μM; 24 hours), inhibits the phosphorylation of eIF4E. At doses of 2.5-40 μM (72 hours), EB1 exhibits dose-dependent cytotoxicity against tumor cells and induces apoptosis. When directly acting on MNK kinase at concentrations of 5 μM, 10 μM, and 20 μM (24 hours), EB1 does not interfere with the activation of upstream signals such as p38 activation (p-p38) and the phosphorylation of its downstream effector HSP27. Compound 14 (EB1) inhibits cancer cells HepG2 and MCF-7 with IC50 values of 0.74 μM and 5.18 μM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MNK2, MNK1

Compound Identifiers

PubChem CID

2048804