EB-47

SKU: orb1709806

Description

EB-47 is a potent and selective PARP-1/ARTD-1 inhibitor (IC₅₀ = 45 nM) that acts as an NAD⁺ mimetic, spanning both the nicotinamide and adenosine subsites. It is a valuable chemical probe for studying PARP-1 function in DNA repair and cellular signaling pathways in both in vitro and in vivo research contexts.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 366454-36-6
• MW: 537.53
• Purity: 99.86% (May vary between batches)
• Formula: C₂₄H₂₇N₉O₆
• SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](C(=O)N4CCN(CC(NC5=C6C(C(=O)NC6)=CC=C5)=O)CC4)[C@H]1O
• Target: PARP
• Solubility: DMSO:60 mg/mL (111.62 mM);H2O:100 mg/mL (186.04 mM)

Bioactivity

• Target IC50:
  ARTD1/PARP1:45 nM
• In Vivo:
  EB-47, at a concentration of 2 μM for a duration of 5 days, reduces the number of embryo implantation sites and the quantity of blastocysts observed on day 5. PARP1 is involved in the embryo implantation process.
• In Vitro:
  The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EB 47, EB47, EB-47, ARTD1/PARP1, ARTD-1, PARP1

Compound Identifiers

PubChem CID

9871899