EAD1 trihydrochloride(1644388-26-0 Free base)

SKU: orb1819264

Description

EAD1 hydrochloride is a potent small molecule autophagy inhibitor with antiproliferative effects, notably in lung and pancreatic cancer cell lines. It also induces apoptosis, making it a useful research tool for investigating cancer biology and cell death mechanisms in vitro.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2320427-95-8
• MW: 593.81
• Purity: 97.49% (May vary between batches)
• Formula: C₂₄H₃₀Cl₅N₇
• SMILES: ClC1=CC=C(CN2N=NC(CNCCN(CCNC3=C4C=CC(Cl)=CC4=NC=C3)C)=C2)C=C1.Cl.Cl.Cl
• Target: Autophagy,Apoptosis
• Solubility: DMSO:55 mg/mL (91.9 mM)

Bioactivity

• Target IC50:
  Autophagy (BxPC3 cells):5.8 μM
• In Vitro:
  EAD1 HCL (0-200 μM; 72 hours) has antiproliferative activity against human cancer cell lines. EAD1 HCL (5-75 μM; 24 hours) induces apoptosis in the H460 cells in a concentration-dependent manner. EAD1 HCL (1-25 μM; 24 hour) increases the punctate LC3 signal in H460 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EAD1 HCL(1644388-26-0 Free base), EAD1 TFA(1644388-26-0 Free base), Apoptosis, Autophagy

Compound Identifiers

PubChem CID

137967115