E6-272

SKU: orb2664143

Description

E6-272 is a small molecule inhibitor of HPV16, inducing apoptosis and inhibiting proliferation in HPV16-positive cervical cancer cell lines such as SiHa and CaSki. Its research applications include investigating HPV oncoprotein function and exploring potential antiviral and anticancer strategies in vitro.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 945142-65-4
• MW: 384.51
• Purity: 99.82% (May vary between batches)
• Formula: C₂₆H₂₈N₂O
• SMILES: O=C(Cc1ccc(cc1)-c1ccccc1)NC1CCN(Cc2ccccc2)CC1
• Target: Virus Protease
• Solubility: DMSO:8 mg/mL (20.81 mM)

Bioactivity

• In Vitro:
  Methods: SIHA and CASKI cells were treated with E6-272 (15nM; 30nM, 48 hours) and apoptosis analysis was performed to evaluate the efficacy of E6-272 in inducing apoptosis in cervical cancer cells. Results: E6-272 (15nM) treatment of SIHA cells induced 27.85% early and 8.38% late apoptotic cell populations (Figure 8). E6-272 (30nM) treatment of CASKI cells showed 23.94% and 7.42% early and late apoptotic cell populations, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E6272, E 6-272

Compound Identifiers

PubChem CID

17250316