E3 ligase Ligand 48

SKU: orb2945927

Description

PROTACAR Degrader-9 (Compound c6) is a CRBN-based PROTAC that selectively degrades the androgen receptor (AR). It demonstrates potent activity in vitro, degrading AR in human dermal papilla cells with a DC50 of 262.38 nM, making it a valuable tool for prostate cancer and androgenetic alopecia research.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Key Properties

• MW: 343.377
• Formula: C₁₈H₂₁N₃O₄
• SMILES: C1CC(CN(C1)C2=CC=C(C=C2)C(=O)NC3CCC(=O)NC3=O)C=O
• Target: Ligands for E3 Ligase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676988