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E3 ligase Ligand 48

SKU: orb2945927

Description

PROTACAR Degrader-9 (Compound c6) is a CRBN-based PROTAC that selectively degrades the androgen receptor (AR). It demonstrates potent activity in vitro, degrading AR in human dermal papilla cells with a DC50 of 262.38 nM, making it a valuable tool for prostate cancer and androgenetic alopecia research.

Research Area

Molecular Biology, Pharmacology & Drug Discovery

Images & Validation

Key Properties

MW343.377
FormulaC18H21N3O4
SMILESC1CC(CN(C1)C2=CC=C(C=C2)C(=O)NC3CCC(=O)NC3=O)C=O
TargetLigands for E3 Ligase

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

Protocol Information