E235

SKU: orb1944656

Description

E235 is a small molecule activator of the transcription factor ATF4. It functions by inducing the integrated stress response (ISR) and activating the DNA damage response pathway. This compound is used in research to study cellular stress, proliferation, and related mechanisms in both in vitro and in vivo models.

Research Area

Cell Biology

Key Properties

• CAS Number: 891894-69-2
• MW: 484.59
• Purity: 98.85% (May vary between batches)
• Formula: C₂₈H₂₅FN₄OS
• SMILES: O=C(NC1CCN(CC=2C=CC=CC2)CC1)C3=CC=C4C(SC5=NC(=CN54)C=6C=CC(F)=CC6)=C3
• Target: PERK,Others
• Solubility: H2O:< 1 mg/mL (Insoluble);DMSO:5 mg/mL (10.32 mM)

Bioactivity

• In Vitro:
  In HT1080, B16F10, and AG1522 cells, E235 (0, 1, 5, and 10 µM; 4 hours) increased ATF4 expression in a dose-dependent manner.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ATF4, E-235, E 235

Compound Identifiers

PubChem CID

22523776