E0924G

• Catalog Number: orb2814174
• Category: Small Molecules
• Description: E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.
• MW: 232.24
• CAS Number: 2909474-29-7
• Formula: C₁₂H₁₂N₂O₃
• SMILES: O=C(NC1=NC=CC(OC)=C1)C=2OC(=CC2)C
• Storage: -20°C
• Note: For research use only