(E)-Akt inhibitor-IV

SKU: orb1298127

Description

(E)-AKT inhibitor-IV is a selective, cell-permeable small molecule that potently blocks the PI3K/Akt signaling pathway. It is widely used in biochemical and cellular research to study cancer, metabolism, and apoptosis, demonstrating utility in both in vitro assays and in vivo xenograft models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 959841-49-7
• MW: 616.56
• Purity: 99.74% (May vary between batches)
• Formula: C₃₁H₂₉IN₄S
• SMILES: CCN(C1/C=C/N(C)c2ccccc2)c(cc(cc2)-c3nc(cccc4)c4s3)c2N1c1ccccc1.I
• Target: Akt
• Solubility: DMSO:50 mg/mL (81.1 mM);10% DMSO+90% Saline:2.5 mg/mL (4.05 mM)

Bioactivity

• In Vitro:
  (E)-Akt inhibitor-IV shows little effects on the growth of 184B5 non-cancer cells at the average GI20 doses

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Protein kinase B, PI3K, PKB, inhibit, Inhibitor, (E) Akt inhibitor IV, (E)Akt inhibitorIV, (E)-AKTIV, Akt, cancer, Akt inhibitor-IV, AKTIV, breast, CS 1992, CS1992, CS-1992

Compound Identifiers

PubChem CID

163285845