E-7386

SKU: orb1309726

Description

E-7386 is a cell-permeable small molecule that modulates the CBP/β-catenin interaction. It is a valuable research tool for investigating Wnt/β-catenin signaling in cancer biology and stem cell research, with utility in both in vitro and in vivo experimental models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1799824-08-0
• MW: 725.85
• Purity: 99.91% (May vary between batches)
• Formula: C₃₉H₄₈FN₉O₄
• SMILES: [H][C@]12CN(Cc3cccc(n3)N3CC(C3)N3CCN(CC)CC3)C(=O)[C@H](Cc3ccc(O)cc3F)N1C(=O)CN(CC=C)N2C(=O)NCc1ccccc1
• Target: Epigenetic Reader Domain
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.51 mM);Methanol:250 mg/mL (344.42 mM);DMSO:125 mg/mL (172.21 mM)

Bioactivity

• In Vivo:
  E-7386 is an oral active CBP/ -catenin regulator, which can induce T cells to infiltrate into the tumor in the Wnt1 tumor cogene mouse model and enhance the anti-tumor activity of anti-PD-1 monoclonal antibody.In the Wnt1 model, t-cell infiltration in the vehicle control group was limited, while t-cell infiltration in the E-7386 treatment group was obvious, and E-7386 showed significant anti-tumor activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CBP, CBP/beta-catenin, E 7386, E7386, E-7386, inhibit, Epigenetic Reader Domain, EpigeneticReaderDomain, Inhibitor

Compound Identifiers

PubChem CID

91810345