(E)-[6]-Dehydroparadol

SKU: orb1708139

Description

(E)-[6]-Dehydroparadol is a bioactive oxidative metabolite of [6]-Shogaol, recognized as a potent activator of the Nrf2 pathway. This small molecule is utilized in research to study antioxidant response mechanisms in both cellular and animal models of oxidative stress.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 878006-06-5
• MW: 276.37
• Purity: 99.87% (May vary between batches)
• Formula: C₁₇H₂₄O₃
• SMILES: CCCCCCCC(=O)\C=C\c1ccc(O)c(OC)c1
• Target: Apoptosis,Nrf2
• Solubility: DMSO:120 mg/mL (434.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.47 mM)

Bioactivity

• Target IC50:
  HCT116 cells:41.59 μM |HCT116 cells:43.02 μM
• In Vivo:
  (E)--Dehydroparadol at a concentration of 5 µM for 24 hours increases the fluorescence signal of Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] in Tg(gstp1:GFP) transgenic zebrafish embryos.
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• In Vitro:
  (E)--Dehydroparadol (5-80 µM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC50s of 43.02 and 41.59 µM, respectively. (E)--Dehydroparadol (10-40 µM; 24 h) induces apoptosis in HCT-116 and H-1299 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

[6]-Dehydroparadol, (6)-Dehydroparadol, HCT-116, Nrf2

Compound Identifiers

PubChem CID

6438480