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DZD9008

SKU: orb1218333

Description

DZD9008 is a rationally designed selective, irreversible EGFR/HER2 inhibitor.

Images & Validation

Key Properties

CAS Number2370013-49-1
MW584.09
Purity>98% (HPLC)
FormulaC29H35ClFN7O3
SMILESCC(C)(c(c(Nc1nc(Nc(cc(c(N(CC2)C[C@H]2N(C)C)c2)NC(C=C)=O)c2OC)ncc1)c1)cc(F)c1Cl)O
TargetHER/HSP
SolubilityIn Vitro: DMSO : 50 mg/mL (85.60 mM)

Bioactivity

In Vitro
(S)-Sunvozertinib shows proliferation inhibition of Ba/F3 EGFR NPH ins (GI50 = 139.7 nM), Ba/F3 FGFR ASV ins (155.7 nM), NCI-HI975 EGFRL858R/T790M (24.4), Her2 YVMA ins (827 nM) and WT EGFR (84.8 nM). (S)-Sunvozertinib shows proliferation inhibition of BTK WT cells (OCI-LY-10, TMD-8, Ri-1and DB, with GI50 ranging from 13.7-48 nM).

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

N-[5-[[4-[5-Chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide

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Protocol Information

DZD9008 (orb1218333)

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% DMSO +
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% Tween 80 +
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Available Sizes

Select a size below

200 mg
500 mg
5 mg
$ 210.00
10 mg
$ 320.00
25 mg
$ 600.00
50 mg
$ 870.00
100 mg
$ 1,230.00