DYRK2-IN-2

SKU: orb3175152

Description

DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2 with an IC50 of 40.3 nM. It exhibits significantly lower inhibitory activity against DYRK1A (IC50 = 1842 nM), DYRK1B (IC50 = 1335 nM), DYRK4 (IC50 = 1931 nM), DYRK3 (IC50 = 112 nM), and CLK proteins (IC50 = 540-6496 nM). DYRK2-IN-2 hinders the phosphorylation of Tau protein at Thr212 and demonstrates moderate cytotoxicity in HT22 cells. This compound is suitable for cancer research.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2416195-65-6
• MW: 384.49
• Formula: C₂₁H₂₄N₂O₃S
• SMILES: S(C[C@H]1CCNC1)C=2C3=C(N=C4C2C=C(OC)C=C4)C(CO)=CC(OC)=C3
• Target: Microtubule Associated,CDK,DYRK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Microtubule Associated,CDK,DYRK