Dyclonine hydrochloride

SKU: orb1224767

Description

Dyclonine is an oral anaesthetic found in Sucrets, an over the counter throat lozenge.(In Vitro):Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH.Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity.\n(In Vivo):Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment in vivo.Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine.

Key Properties

• CAS Number: 536-43-6
• MW: 325.87
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₇NO₂·HCl
• SMILES: CCCCOC1=CC=C(C=C1)C(=O)CCN2CCCCC2.Cl
• Target: Sodium Channel
• Solubility: Ethanol: 36 mg/mL (110.47 mM); Water: 6 mg/mL (18.41 mM); DMSO: 15 mg/mL (46.03 mM)

Bioactivity

• In Vivo:
  Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 24 days) sensitizes the involucrin+ differentiated tumor cells to sulfasalazine treatment In vivo. Dyclonine hydrochloride (5 mg/kg; i.p.; single daily for 21 days) suppress the growth of tumors formed by ALDH3A1-expressing gastric cancer stemlike cells when combines with sulfasalazine. Animal model: Athymic nude mice (HSC-2 cells implanted model). Dosage: 5 mg/kg. Administration: Intraperitoneal injection; single daily for 24 days (combine with sulfasalazine). Result: Attenuated the formation of tumors by HSC-2 cells implanted in nude mice when combined with sulfasalazine. Animal model: C57BL6 mice (K19-Wnt1/C2mE-KP cells implanted model). Dosage: 5 mg/kg. Administration: Intraperitoneal injection; single daily for 21 days (combine with sulfasalazine). Result: Enhanced the antitumor effect of sulfasalazine on HNSCC tumors consisting of CD44vhigh stemlike tumor cells and involucrin+ differentiated tumor cells.
• In Vitro:
  Dyclonine hydrochloride (50 μM; 24 h) sensitizes cancer cells to deficiency of cysteine and GSH. Dyclonine hydrochloride (0-2048 μg/mL; 24 or 48 h) shows significant bactericidal and fungicidal activity. Cell Viability Assay Cell line: HSC-4 cells. Concentration: 50 μM. Incubation time: 24 h. Result: Inhibited ALDH activity and induced 4-HNE accumulation in GSH-depleted cancer cells. Cell Viability Assay Cell line: S. aureus, B. subtilis, E. coli, T. mentagrophyte Concentration: 0-2048 μg/mL. Incubation time: 24 h (for bacterial), 48 h (for fungi). Result: Showed good antibacterial and antifungal activity, with minimum microbicidal concentration of 0.006%, 0.025%, 0.012% and 0.025% for S. aureus, B. subtilis, E. coli, T. mentagrophyte, separately.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dyclonine Hydrochloride | Dyclonine HCL | Dyclone | Dyclothane | Tanaclone | Sucrets | Tanac

Quick Database Links

Gene Symbol

Sodium Channel