DW14800

SKU: orb1710790

Description

DW14800 is a potent and selective PRMT5 inhibitor (IC50 = 17 nM) that reduces histone H4R3 symmetric dimethylation (H4R3me2s) and subsequently upregulates HNF4α transcription. This small molecule is a valuable chemical probe for investigating PRMT5 biology in epigenetic regulation, cancer research, and metabolic studies in both cellular and animal models.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2243709-60-4
• MW: 512.64
• Purity: 99.68% (May vary between batches)
• Formula: C₃₁H₃₆N₄O₃
• SMILES: C(=O)(N1CC=2C(=CC(C(NCC(CN3CC=4C(CC3)=CC=CC4)O)=O)=CC2)CC1)C5=CC=C(N(C)C)C=C5
• Target: Histone Methyltransferase
• Solubility: DMSO:45 mg/mL (87.78 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.9 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Histone Methyltransferase, HistoneMethyltransferase, DW 14800, DW14800, DW-14800, PRMT5

Compound Identifiers

PubChem CID

138454790