Duvelisib hydrate

• Catalog Number: orb1738678
• Category: Small Molecules
• Description: Duvelisib hydrate
• Purity: 98.00%
• MW: 434.884
• Biological Activity: Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases.
• CAS Number: 1386861-49-9
• Formula: C₂₂H₁₉ClN₆O₂
• SMILES: O.C[C@H](Nc1ncnc2nc[nH]c12)c1cc2cccc(Cl)c2c(=O)n1-c1ccccc1
• Storage: -20°C
• Note: For research use only