Duocarmycin TM

SKU: orb1309731

Description

Duocarmycin TM is a potent small molecule DNA alkylating agent with significant antitumor activity. It is widely used in cancer research, demonstrating efficacy in both in vitro cytotoxicity assays and in vivo models of tumor growth inhibition.

Research Area

Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 157922-77-5
• MW: 466.91
• Purity: 99.15% (May vary between batches)
• Formula: C₂₅H₂₃ClN₂O₅
• SMILES: COc1cc2cc([nH]c2c(OC)c1OC)C(=O)N1C[C@@H](CCl)c2c1cc(O)c1ccccc21
• Target: DNA Alkylator/Crosslinker,Antibiotic,DNA Alkylation,ADC Cytotoxin
• Solubility: DMSO:50 mg/mL (107.09 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.28 mM)

Bioactivity

• Target IC50:
  CHO-AA8 cells:0.21 nM|UV4 cells:0.09 nM|EMT6 cells:0.13 nM|SKOV3 cells:0.29 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CBI-TMI, DNA Alkylation, DNA Alkylator, DNA Alkylator/Crosslinker, DNAAlkylation, Duocarmycin TM, duplex DNA, BJAB cell, Antitumor, Antibiotic, alkylation, ADCCytotoxin, ADC Cytotoxin, ADC Payload, inhibit, Inhibitor, WSU-DLCL2 cell

Compound Identifiers

PubChem CID

394851