DUB-IN-1

SKU: orb1309735

Description

DUB-IN-1 is a potent and selective small molecule inhibitor of USP8, demonstrating an IC50 of 0.24 µM. This compound is a valuable chemical probe for investigating deubiquitinase function in cancer research and cellular signaling pathways, useful for both in vitro and cell-based assays.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 924296-18-4
• MW: 337.33
• Purity: 98.50% (May vary between batches)
• Formula: C₂₀H₁₁N₅O
• SMILES: N#Cc1nc2\C(=N\OCc3ccccc3)c3ccccc3-c2nc1C#N
• Target: DUB
• Solubility: DMSO:45 mg/mL (133.4 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.93 mM)

Bioactivity

• Target IC50:
  USP8:0.24 μM
• In Vitro:
  DUBs-IN-1 is inactive toward USP7 (IC50, >100 μM). DUBs-IN-1 and its analogs reduce the viability of HCT116 colon and PC-3 prostate cancer cell lines with IC50s ranging from 0.5 μM to 1.5 μM.DUBs-IN-1 (22 f) is an active inhibitor of ubiquitin-specific proteases, with an IC50 of 0.24 μM for USP8.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP8, Inhibitor, inhibit, Deubiquitinase, DUB IN 1, DUBIN1, DUB-IN-1, DUBs

Compound Identifiers

PubChem CID

16065490