DTP3

SKU: orb1218593

Description

DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.

Key Properties

• CAS Number: 1809784-29-9
• MW: 525.6
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₅N₇O₅
• SMILES: CC(=O)N[C@H](CC1=CC=C(C=C1)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@H](CC2=CC=CC=C2)C(=O)N
• Target: GADD45β/MKK7
• Solubility: DMSO:100 mg/ml (190.26 mM); Ethanol:100 mg/ml (190.26 mM); Water:100 mg/ml (190.26 mM)

Bioactivity

• In Vivo:
  Animal model: 6 to 8-week old male NOD/SCID mice (NOD. CB17-Prkdcscid/IcrCrl; Charles River). Dosage: 14.5 mg/kg. Administration: S. c. ; daily; 28 days. Result: Had shown a dramatic shrinkage of the tumors. Animal model: CD1 male mice of 25-30 g. Dosage: 10 mg/kg (Pharmacokinetic Study). Administration: Intravenous injection. Result: Had t1/2 of 1.26 hours, CL of 27.13 ML/min/kg, and Vd of 2.80 L/kg.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GADD45β/MKK7