DSS30

SKU: orb1688596

Description

DSS30 is a small molecule inhibitor targeting P25/CDK5, which reduces β-amyloid secretion by inhibiting BACE1 phosphorylation. It serves as a research tool for studying Alzheimer's disease mechanisms and has shown potential in cellular and animal models of neurodegeneration.

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 883027-32-5
• MW: 367.87
• Purity: >99.99% (May vary between batches)
• Formula: C₁₆H₁₄ClNO₃S₂
• SMILES: CC=1C=2C(SC1S(NC3=C(OC)C=CC=C3)(=O)=O)=CC=C(Cl)C2
• Target: BACE,CDK,Beta Amyloid
• Solubility: DMSO:10 mg/mL (27.18 mM)

Bioactivity

• In Vitro:
  DSS30 (50 μM, 2 h) demonstrates a maximum 50% inhibition in the P25/CDK5 complex activity, along with a reduction in the phosphorylation levels of BACE1 or Tau.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

bAmyloid, BACE1, b Amyloid, Aβ, CDK5/p25, Beta Amyloid, BetaAmyloid, βAmyloid, β Amyloid

Compound Identifiers

PubChem CID

2824096