DSM265

SKU: orb1707356

Description

DSM265 is a potent and selective inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (DHODH), exhibiting antimalarial activity with an IC50 of 8.9 nM against Pf3D7 strains. It has demonstrated efficacy in both in vitro parasite growth assays and in vivo models for the treatment and prophylaxis of malaria.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1282041-94-4
• MW: 415.33
• Purity: 99.79% (May vary between batches)
• Formula: C₁₄H₁₂F₇N₅S
• SMILES: Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2nc(nc2n1)C(C)(F)F
• Target: Dehydrogenase|||Parasite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.82 mM);H2O:< 0.1 mg/mL (insoluble.);DMSO:30 mg/mL (72.23 mM);Ethanol:5 mg/mL (12.04 mM)

Bioactivity

• Target IC50:
  P. falciparum (3D7 parasites):4.3 nM (EC50)|PfDHODH:8.9 nM
• In Vivo:
  In NOD-scid IL-2Rγnull (NSG) mice (23-36 g), DSM265 (0.5 - 75 mg/kg; oral administration; twice daily; for 4 days) exhibited potent antimalarial activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DHODH, DSM 265, DSM265, DSM-265, PfDHODH, PfSPZ, P. falciparum 3D7 parasites, P. falciparum

Compound Identifiers

PubChem CID

51347395