DSM265

SKU: orb1707356

Description

DSM265

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 1282041-94-4
• MW: 415.33
• Purity: 99.79%
• Formula: C₁₄H₁₂F₇N₅S
• SMILES: Cc1cc(Nc2ccc(cc2)S(F)(F)(F)(F)F)n2nc(nc2n1)C(C)(F)F
• Target: Dehydrogenase,Parasite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.82 mM);H2O:< 0.1 mg/mL (insoluble.);DMSO:30 mg/mL (72.23 mM);Ethanol:5 mg/mL (12.04 mM)

Bioactivity

• Target IC50:
  P. falciparum (3D7 parasites):4.3 nM (EC50)|PfDHODH:8.9 nM
• In Vivo:
  In NOD-scid IL-2Rγnull (NSG) mice (23-36 g), DSM265 (0.5 - 75 mg/kg; oral administration; twice daily; for 4 days) exhibited potent antimalarial activit.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

DHODH, DSM 265, DSM265, DSM-265, PfDHODH, PfSPZ, P. falciparum 3D7 parasites, P. falciparum

Compound Identifiers

PubChem CID

51347395