DS20362725

SKU: orb1689271

Description

DS20362725 is a selective ERRα agonist that enhances its transcriptional activity by disrupting its interaction with the repressor RIP140. This compound is a valuable research tool for studying ERRα's role in metabolic disorders, including in vitro assays and in vivo metabolic disease models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2735803-20-8
• MW: 310.39
• Purity: 99.34% (May vary between batches)
• Formula: C₁₉H₂₂N₂O₂
• SMILES: OC1=CC=C(OC=2C=CC=3N=C(N(C3C2)C)C)C=C1C(C)(C)C
• Target: Estrogen/progestogen Receptor,Estrogen Receptor/ERR
• Solubility: DMSO:5 mg/mL (16.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.22 mM)

Bioactivity

• In Vitro:
  Treatment of MG63 cells with DS20362725 (0.002, 0.006, 0.017, 0.051, 0.015, 0.046, 1.4, 4.2, 12.5 μg/mL, 18 hours) activated the transcriptional activity of full-length ERRα with an EC50 value of 1.1 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DS 20362725

Compound Identifiers

PubChem CID

162641550