DS16570511

SKU: orb1309738

Description

DS16570511 is a cell-permeable small molecule that selectively inhibits the mitochondrial calcium uniporter (MCU) complex, blocking MCU- and MICU1-dependent Ca²⁺ uptake. This inhibitor is a valuable research tool for studying mitochondrial calcium signaling in cellular and in vivo models of ischemia-reperfusion injury and neurodegeneration.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2446154-84-1
• MW: 562.44
• Purity: 98.45% (May vary between batches)
• Formula: C₃₀H₂₅Cl₂N₃O₄
• SMILES: C(=O)(C=1C=2C(N(CCCC(O)=O)C1)=CC=CC2)C3=CC(NCC=4C(=NOC4C)C5=C(Cl)C=CC=C5Cl)=CC=C3
• Target: Calcium Channel
• Solubility: DMSO:124 mg/mL (220.47 mM)

Bioactivity

• In Vitro:
  DS16570511 effectively inhibits serum-induced mitochondrial Ca2+ (calcium) influx in HEK293A cells in a dose-dependent manner, exhibiting an IC50 value of 7 μM. Additionally, it suppresses calcium uptake in isolated mitochondria sourced from human cells, rat, and pig hearts.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mitochondrial calcium uniporter, Mitochondrial calcium uniporter, CalciumChannel, Calcium Channel, DS 16570511, DS16570511, DS-16570511

Compound Identifiers

PubChem CID

137700533