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DS-PPE-GW

SKU: orb3175794

Description

DS-PPE-GW is a BCR-ABLATTEC degrader. This compound links BCR-ABL and LC3B, anchoring BCR-ABL to the autophagosome membrane. DS-PPE-GW demonstrates potent BCR-ABL degradation capability and exhibits anticancer activity against chronic myeloid leukemia (Pink: LC3B ligand; Blue: BCR-ABL ligand; Black: linker).

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

TargetBcr-Abl,ATTECs,Autophagy

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information