DS-7423

SKU: orb1304003

Description

DS-7423 is a potent dual inhibitor targeting both PI3Kα and mTOR with nanomolar IC50 values, while showing lower potency against other class I PI3K isoforms. This small molecule is used in preclinical research to investigate PI3K/mTOR pathway signaling in cancer models, both in vitro and in vivo.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1222104-37-1
• MW: 520.51
• Purity: 99.98% (May vary between batches)
• Formula: C₂₂H₂₇F₃N₁₀O₂
• SMILES: C[C@@H]1CN(CCN1C(C)=O)c1nc2c(nc(nc2n1CC(F)(F)F)-c1cnc(N)nc1)N1CCOCC1
• Target: mTOR,PI3K
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.84 mM);DMSO:65 mg/mL (124.88 mM)

Bioactivity

• Target IC50:
  PI3Kδ:262 nM|PI3Kβ:1143 nM|PI3Kα:15.6 nM|mTOR:34.9 nM|PI3Kγ:249 nM
• In Vitro:
  DS-7423 elevates TP53 expression, enhances p-TP53 on Ser-46 phosphorylation, and stimulates apoptosis-related TP53 target genes (TP53AIP1 and PUMA) in OCCC cells. Additionally, it selectively inhibits class I PI3K isoforms with varying IC50 values: PI3Kβ at 1,143 nM, PI3Kγ at 249 nM, and PI3Kδ at 262 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TP53, TP53AIP1, PUMA, PI3Kα, PI3K, Phosphoinositide 3-kinase, DS7423, DS-7423, DS 7423, Mammalian target of Rapamycin, Inhibitor, mTOR, inhibit, OCCC

Compound Identifiers

PubChem CID

45378170