Drospirenone

SKU: orb1224282

Description

Drospirenone is a synthetic progestin that is an analog to spironolactone. It is found in a number of birth control formulations. Drospirenone differs from other synthetic progestins in that its pharmacological profile in preclinical studies shows it to be closer to the natural progesterone. As such it has anti-mineralocorticoid properties, counteracts the estrogen-stimulated activity of the renin-angiotensin-aldosterone system, and is not androgenic. It was shown in animal studies that drospirenone exhibits antiandrogenic activity judging from accessory sex gland growth in castrated, androgen-treated, juvenile rats.

Key Properties

• CAS Number: 67392-87-4
• MW: 366.49
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₀O₃
• SMILES: O=C1CC[C@]2(C)[C@@]3([H])CC[C@@]([C@](OC4=O)(CC4)[C@]5([H])[C@@]6([H])C5)(C)[C@]6([H])[C@]3([H])C7C(C7)C2=C1
• Target: Androgen Receptor (AR)
• Solubility: Ethanol: 11 mg/mL (30.01 mM); DMSO: 73 mg/mL (199.18 mM)

Bioactivity

• In Vivo:
  Animal model: Adult female mice. Dosage: 10 mg/kg, 100 mg/kg. Administration: Oral gavage (p.o.). Result: Caused DNA damage at dose rates of 10 and 100 mg/kg. Enhanced the genotoxicity combinated with ethinylestradiol.
• In Vitro:
  Cell Cytotoxicity Assay Cell line: PLHC-1 cell. Concentration: 10-150 μM. Incubation time: 24 h, 48 h. Result: Caused a 50% decline in cell viability with the effective concentration of 102-119 μM after 24 h exposure and 51-58 μM after 48 h exposure.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1,2-dihydro Spirorenone | ZK 30595

Quick Database Links

Gene Symbol

Androgen Receptor (AR)