Dronedarone

SKU: orb1300105

Description

Dronedarone

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 141626-36-0
• MW: 556.76
• Purity: 98.85% (May vary between batches)
• Formula: C₃₁H₄₄N₂O₅S
• SMILES: CCCCN(CCCC)CCCOc1ccc(cc1)C(=O)c1c(CCCC)oc2ccc(NS(C)(=O)=O)cc12
• Target: Adrenergic Receptor,Cytochromes P450,Potassium Channel,AChR,Autophagy,Calcium Channel,Sodium Channel
• Solubility: DMSO:50 mg/mL (89.81 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.59 mM)

Bioactivity

• In Vivo:
  Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction .
• In Vitro:
  Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes . Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts . Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold) = -40 mV with IC50 value of 0.4 μM, whereas at V (hold) = -80 mV, Dronedarone (10 μM) blocks only 20 % of the current .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Na channels, Na+ channels, mAChR, Muscarinic acetylcholine receptor, inhibit, inoatrial nodal, Inhibitor, Ca channels, Calcium channel, Calcium Channel, Ca2+ channels, antiadrenergic, Autophagy, atrial flutter, atrial myocyte, Adrenergic Receptor, AdrenergicReceptor, coronary perfusion, Beta Receptor, CalciumChannel, Dronedarone, Cytochrome P450, CYPs, Potassium Channel, potassium current, PotassiumChannel, SodiumChannel, Sodium Channel, Sodium channel, SR 33589, SR33589, SR-33589

Compound Identifiers

PubChem CID

208898