DRI-C21045

SKU: orb1309740

Description

Dri-c21045 concentration-dependently inhibits NF-κB activation and CD40L-induced B cell proliferation with IC50 values of 17.1 μM and 4.5 μM, respectively. It selectively blocks the CD40-CD40L protein-protein interaction (IC50 = 0.17 μM) and is applied in immunological research, including in vitro and in vivo studies of autoimmune diseases.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2101765-81-3
• MW: 580.61
• Purity: 98.10%
• Formula: C₃₂H₂₄N₂O₇S
• SMILES: COC(=O)c1ccc(cc1)C(=O)Nc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1cccc2cccc(c12)S(O)(=O)=O
• Target: TNF,NF-κB
• Solubility: DMSO:2 mg/mL (3.44 mM)

Bioactivity

• Target IC50:
  CD40:0.17 µM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DRI C21045, DRI-C 21045, DRIC21045, DRI-C21045, DRI-C-21045, NF-kB, NFkB, NFκB, NF-κB, inhibit, Inhibitor, TNFR, TNF Receptor, Tumor Necrosis Factor Receptor

Compound Identifiers

PubChem CID

129275747